依托国家工业结晶工程技术中心开展工业结晶科学与技术研究：1）基于人工智能的结晶过程分析技术与过程控制；2）结晶过程连续化与过程强化；3）超纯熔融结晶；4）新型工业结晶过程与仪器装备设计。

1. 博士研究生课程《现代颗粒科学与晶体形态学》

2. 硕士研究生课程《工业结晶与粒子过程》

3. 留学生课程《Computer Simulation of Chemical Processes》

期刊Crystals, Processes客座编辑,期刊Asian Journal of Pharmaceutical Sciences青年编辑；期刊 JACS, Angewandte Chemie, AIChE J, Chem Eng. J, Cystal Growth and Design等审稿人。

河北医药科技进步一等奖；中国商业联合会三等奖

主持怀柔国家实验室、国家自然科学基金、省部级重点研发课题6项，产学研项目18项。主要代表性课题包括：

（1）怀柔国家实验室重大科研任务子课题“液化油高效结晶分离”，负责人；

（2）国家自然科学基金面上项目“结晶过程智能化设计与模拟放大机制研究”，项目编号22578316，负责人；

（3）国家自然科学基金面上项目“药物结晶及其二次过程的智能谱图软测量和模型预测控制”，项目编号22378296，负责人；

（4）国家自然科学基金青年项目“基于图像+AI技术的溶液结晶原位显微监测与过程数据挖掘”，项目编号22008173，负责人；

（5）山东省重大研发计划“高端原料药精准微粉化共性关键技术创新、制剂产业化及一致性评价研究”，课题“药物结晶制备超细晶体药物”，项目编号2021CXGC010514，负责人；

（6）广西壮族自治区揭榜挂帅重点项目“糖业大模型研发与应用示范项目”，课题 “煮糖结晶的相变动力学及控制机制”，项目编号JB2502850006, 负责人；

（7）重质芳烃高值低碳熔融结晶技术研发, 负责人；

（8）六氟磷酸锂连续结晶工艺及技术装备开发, 负责人；

（9）特定晶型阿立哌唑和盐酸多奈哌齐结晶新技术与新设备研发, 负责人；

（10）2-硝基氯甲苯混合物分离精制技术研发与产业化，负责人

一、代表性专著、论文：

1. Junbo Gong, Zhenguo Gao*. Chapter 1: Process Control and Intensification of Solution Crystallization Optimization of Pharmaceutical Processes (Panos Pardalos, My T. Thai)- Springer Optimization and Its Applications Book series. Print ISSN 1931-6828.

2. Jian Liu, Tuo Yao, Muyang Li, Sohrab Rohani, Jingkang Wang, Zhenguo Gao *, Junbo Gong. Computer Vision–Assisted High-Throughput Screening of Crystallization Additives for Crystal Size, Shape, and Agglomeration Regulation, Engineering, https://doi.org/10.1016/j.eng.2025.02.023;

3. Zhenguo Gao, Sohrab Rohani, Junbo Gong, Jingkang Wang. Recent developments in the crystallization process: toward pharmaceutical industry. Engineering, 3,2017, 343-353;

4. Tuo Yao, Jian Liu, Xuxing Wan, Beibei Li, Sohrab Rohani, Zhenguo Gao*, Junbo Gong, Deep-learning based in-situ image monitoring crystal polymorph and size distribution: modeling and validation, AIChE J, 2023, 18279.

5. Shengzhe Jia, Liuyang Yu, Zhenguo Gao*, Songgu Wu, Weiwei Tang*, Jingkang Wang, Junbo Gong, Performance and analysis of key factors on the design of melt crystallization‐based separation process. AIChE J, 2023, 18117.

6. Shengzhe Jia, Zhenguo Gao*, Tuo Yao, Jingkang Wang, Junbo Gong, Fractal Model-Based Crystal Pillar Structure Simulation and Mechanism Analysis of Impurity Migration Process in Layer Melt Crystallization. Chemical Engineering Science, 275, (2023): 118722.

7. Lan Fang, Zhenguo Gao*, Zhenjie Gao, Wenfeng Huang, Xuxing Wan, Sohrab Rohani, Junbo Gong*, Controlled Crystallization of Metastable Polymorphic Pharmaceutical: Comparative Study of Batchwise and Continuous Tubular Crystallizers. Chemical Engineering Science, 266, (2023): 118277.

8. Shengzheng Guo, Ziyi Liu, Yuxin Zhang, Jingkang Wang, Zhenguo Gao*, Junbo Gong. Cryo-Crystallization of Inhalable Budesonide Ultrafine Crystals with Enhanced Aerosol Performance: Mechanism and Evaluation. ACS Appl. Mater. Interfaces, 17, 2025, 39999–40011.

9. Ziyi Liu, Yun Cao, Muyang Li, Jian Liu, Jiaxing Hu, Zhenguo Gao*, Junbo Gong, Impact of surface chemistry on the solid-state stability and release behavior of Nano-confined amorphous Vortioxetine, Chemical Engineering Journal, 520, 2025, 165898,

10. Jian Liu, Min Li, Jingwei Cai, Tuo Yao, Leping Dang, Sohrab Rohani, Zhenguo Gao*, Junbo Gong. A deep learning-powered intelligent microdroplet analysis workflow for in-situ monitoring and evaluation of a dynamic emulsion. Chemical Engineering Journal, 499 (2024), 155927.

11. Timothy Hutagaol, Jian Liu, Muyang Li, Zhenguo Gao*, Junbo Gong. Enhanced Powder Characteristics of Succinic Acid through Crystallization Techniques for Food Industry Application. Journal of Food Engineering, 388 (2024), 112376.

12. Wei Hong, Shengzhe Jia, Yongjun Chen, Qilin Mou, Zhenguo Gao*, Junbo Gong, Highly Efficient and Solvent-Free Purification Technique and Model Study of Layer Melt Crystallization. ACS Sustainable Chem. Eng., 2022, 10, 49, 16450–16458.

二、代表性专利：

1） 一种超声强化的对称射流耦合段塞流结晶系统装置及其应用，ZL202210937527.1

2） 一种灰黄霉素超细晶体的制备方法，ZL202310549138.6

3） 一种阿立哌唑B晶型的结晶方法；ZL202210241612.4

4） 一种疏水球晶、疏水材料、疏水复合材料、Janus复合材料及其制备方法和应用，ZL202110143150.8

5） 头孢噻肟钠N-N二甲基甲酰胺溶剂化合物及制备方法, ZL 201410020280.2

6） 一种制备头孢噻肟钠晶体的方法, ZL 201510264083.X

7） 一种内嵌式湿磨结晶器, ZL202320285913.7

8） 一种坎地沙坦酯纳米晶体的制备方法, ZL202311320005.8

9） 一种粒度可调的吸入型布地奈德超细晶体制备方法, CN116650449A

10） 一种非诺贝特超细管状晶体的制备方法, CN117466738A