核酸化学生物学与功能材料:以生物大分子DNA为研究主线,聚焦DNA生物功能材料化学组装,探究生命系统运行机制,探索重大疾病的诊断治疗新途径。
DNA合成
《Advanced Functional Materials》编委(2023-)
《Chinese Chemical Letters》编委(2020-)
中国生物医学工程学会纳米医学与工程分会委员(2019-2023)
中国抗癌协会纳米肿瘤学专委会委员(2021-2025)
聚焦生物材料化学领域重大基础科学问题和应用需求,开展DNA化学组装与功能材料研究,融合DNA化学与生命边界,建立DNA组装新方法,合成多种具有应用潜力的DNA功能材料,开拓肿瘤治疗新途径,打通DNA材料基础研究和医学应用全链条。获国家杰出青年基金、国家优秀青年基金、国家重点研发计划、国家海外高层次人才计划、天津市杰青项目等。获得中国化工学会基础研究成果奖二等奖(1/3)。以通讯作者在Chem Rev、Acc Chem Res、PNAS、J Am Chem Soc、Angew Chem、Nat Commun、Nat Protoc、Sci Adv和Adv Mater等杂志发表学术论文150余篇。申请发明专利55项,授权24项。出版专著和教材两部:《合成基因组学》(科学出版社,2020)、《核酸功能材料》(科学出版社,2024)
国家杰出青年基金、国家自然科学基金优青项目、国家重点研发计划课题
论著:
《合成基因组学》,科学出版社,2020.10
《核酸功能材料》,科学出版社,2024.3
论文:
1. Nachuan Song+, Hongjin Li+, Chi Yao*, Dayong Yang*, Dynamic Chemistry of DNA-Based Nanoassemblies in Living Cells, Accounts of Chemical Research, 2024, 57, 2763.
2. Sen Yang+, Junlin Wu+, Zhongyu Wang, Yu Cheng, Rui Zhang, Chi Yao*, Dayong Yang*, A Smart DNA Hydrogel Enables Synergistic Immunotherapy and Photodynamic Therapy of Melanoma. Angewandte Chemie International Edition, 2024, in press.
3. Nachuan Song+, Xiaoting Fan+, Xiaocui Guo+, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*, A DNA/Upconversion Nanoparticle Complex Enables Controlled Co-Delivery of CRISPR-Cas9 and Photodynamic Agents for Synergistic Cancer Therapy. Advanced Materials, 2024, in press.
4. Yanfei Guo, Siqi Li, Zhaobin Tong, Jianpu Tang, Rui Zhang, Zhaoyue Lv, Nachuan Song, Dayong Yang*, Chi Yao*, Telomerase-Mediated Self-Assembly of DNA Network in Cancer Cells Enabling Mitochondrial Interference. Journal of the American Chemical Society, 2023, 145, 23859.
5. Nachuan Song+, Yiwen Chu+, Shuai Li, Yuhang Dong, Xiaoting Fan, Jianpu Tang, Yanfei Guo, Guangshuai Teng, Chi Yao*, Dayong Yang*, Cascade Dynamic Assembly/Disassembly of DNA Nanoframework Enabling the Controlled Delivery of CRISPR-Cas9 System. Science Advances, 2023, 9, eadi3602.
6. Zhaoyue Lv+, Mengxue Huang+, Jing Yang+, Peiran Li, Lele Chang, Qianyun Tang, Xiaojing Chen, Shengqi Wang*, Chi Yao*, Peifeng Liu*, Dayong Yang*, A Smart DNA-Based Nanosystem Containing Ribosome-Regulating siRNA for Enhanced mRNA Transfection. Advanced Materials, 2023, 35, 2300823.
7. Jianpu Tang+, Xuemei Jia+, Qian Li+, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang*, Chi Yao*, A DNA-Based Hydrogel for Exosome Separation and Biomedical Applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120.
8. Fengqin Li+, Junru, Li+, Weiqiang Yang+, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang*, Xiaolei Zuo*, Peifeng Liu*, Framework-Hotspot Enhanced Trans Cleavage of CRISPR-Cas12a for Clinical Samples Detection. Angewandte Chemie International Edition, 2023, 62, e202305536.
9. Chi Yao+*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic Assembly of DNA-Ceria Nanocomplex in Living Cells Generates Artificial Peroxisome. Nature Communications, 2022, 13, 7739.
10. Chi Yao+, Junhan Ou+, Jianpu Tang+, Dayong Yang*, DNA Supramolecular Assembly on Micro/Nanointerfaces for Bioanalysis. Accounts of Chemical Research, 2022, 55, 2043.
研究生导师类型 |
学术型硕导,专业型硕导,学术型博导,专业型博导 |
学术型硕士招生学科 |
081703生物化工,083201食品科学 |
学术型硕士招生研究方向 |
00不区分研究方向 |
专业型硕士招生学科 |
086000生物与医药(专业学位) |
专业型硕士招生研究方向 |
02生物工程 |
学术型博士招生学科 |
081703生物化工 |
专业型博士招生学科 |
086000生物与制药 |