核酸化学生物学与功能材料：以生物大分子DNA为研究主线，聚焦DNA生物功能材料化学组装，探究生命系统运行机制，探索重大疾病的诊断治疗新途径。

DNA合成

《Advanced Functional Materials》编委（2023-）

《Chinese Chemical Letters》编委（2020-）

中国生物医学工程学会纳米医学与工程分会委员（2019-2023）

中国抗癌协会纳米肿瘤学专委会委员（2021-2025）

聚焦生物材料化学领域重大基础科学问题和应用需求，开展DNA化学组装与功能材料研究，融合DNA化学与生命边界，建立DNA组装新方法，合成多种具有应用潜力的DNA功能材料，开拓肿瘤治疗新途径，打通DNA材料基础研究和医学应用全链条。获国家杰出青年基金、国家优秀青年基金、国家重点研发计划、国家海外高层次人才计划、天津市杰青项目等。获得中国化工学会基础研究成果奖二等奖（1/3）。以通讯作者在Chem Rev、Acc Chem Res、PNAS、J Am Chem Soc、Angew Chem、Nat Commun、Nat Protoc、Sci Adv和Adv Mater等杂志发表学术论文150余篇。申请发明专利55项，授权24项。出版专著和教材两部：《合成基因组学》（科学出版社，2020）、《核酸功能材料》（科学出版社，2024）

国家杰出青年基金、国家自然科学基金优青项目、国家重点研发计划课题

论著：

《合成基因组学》，科学出版社，2020.10

《核酸功能材料》，科学出版社，2024.3

论文：

1. Nachuan Song+, Hongjin Li+, Chi Yao*, Dayong Yang*, Dynamic Chemistry of DNA-Based Nanoassemblies in Living Cells, Accounts of Chemical Research, 2024, 57, 2763.

2. Sen Yang+, Junlin Wu+, Zhongyu Wang, Yu Cheng, Rui Zhang, Chi Yao*, Dayong Yang*, A Smart DNA Hydrogel Enables Synergistic Immunotherapy and Photodynamic Therapy of Melanoma. Angewandte Chemie International Edition, 2024, in press.

3. Nachuan Song+, Xiaoting Fan+, Xiaocui Guo+, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*, A DNA/Upconversion Nanoparticle Complex Enables Controlled Co-Delivery of CRISPR-Cas9 and Photodynamic Agents for Synergistic Cancer Therapy. Advanced Materials, 2024, in press.

4. Yanfei Guo, Siqi Li, Zhaobin Tong, Jianpu Tang, Rui Zhang, Zhaoyue Lv, Nachuan Song, Dayong Yang*, Chi Yao*, Telomerase-Mediated Self-Assembly of DNA Network in Cancer Cells Enabling Mitochondrial Interference. Journal of the American Chemical Society, 2023, 145, 23859.

5. Nachuan Song+, Yiwen Chu+, Shuai Li, Yuhang Dong, Xiaoting Fan, Jianpu Tang, Yanfei Guo, Guangshuai Teng, Chi Yao*, Dayong Yang*, Cascade Dynamic Assembly/Disassembly of DNA Nanoframework Enabling the Controlled Delivery of CRISPR-Cas9 System. Science Advances, 2023, 9, eadi3602.

6. Zhaoyue Lv+, Mengxue Huang+, Jing Yang+, Peiran Li, Lele Chang, Qianyun Tang, Xiaojing Chen, Shengqi Wang*, Chi Yao*, Peifeng Liu*, Dayong Yang*, A Smart DNA-Based Nanosystem Containing Ribosome-Regulating siRNA for Enhanced mRNA Transfection. Advanced Materials, 2023, 35, 2300823.

7. Jianpu Tang+, Xuemei Jia+, Qian Li+, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang*, Chi Yao*, A DNA-Based Hydrogel for Exosome Separation and Biomedical Applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120.

8. Fengqin Li+, Junru, Li+, Weiqiang Yang+, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang*, Xiaolei Zuo*, Peifeng Liu*, Framework-Hotspot Enhanced Trans Cleavage of CRISPR-Cas12a for Clinical Samples Detection. Angewandte Chemie International Edition, 2023, 62, e202305536.

9. Chi Yao+*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic Assembly of DNA-Ceria Nanocomplex in Living Cells Generates Artificial Peroxisome. Nature Communications, 2022, 13, 7739.

10. Chi Yao+, Junhan Ou+, Jianpu Tang+, Dayong Yang*, DNA Supramolecular Assembly on Micro/Nanointerfaces for Bioanalysis. Accounts of Chemical Research, 2022, 55, 2043.