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董敏 教授

制药工程系

本科,硕士毕业于天津大学,博士毕业于北京大学,香港大学和美国康奈尔大学历任博士后,助理研究员,2019年加入天津大学。

  • 电子邮箱:mindong@tju.edu.cn

  • 办公电话:13661009121

  • 个人网站:http://chemeng.tju.edu.cn/cn/szdw?type=detail&subtype=11&id=488

科研方向阐述

天然产物生物合成,酶催化,金属酶


讲授课程

生物化学与化学生物学;英文科技论文写作

学术兼职

中国医药生物技术协会酶工程与发酵工程专业委员会委员

学术成就

入选国家级人才计划青年项目,天津市海外高层次人才青年项目,天津大学“北洋青年学者”。主要从事天然产物、蛋白质翻译后修饰的生物合成研究,特别是金属酶的功能和催化机制解析,以及酶促非天然反应的研究。近年来在Science, JACS, ACS catalysis等期刊发表学术论文多篇。现主持合成生物学领域国家自然科学基金和天津市自然基金等项目。

项目案例

论著专利

After join TJU

19. Yao, Y.; He, J.; Chen, F.; Dong, M.*. Arsinothricin Biosynthesis Involving a Radical SAM Enzyme for Noncanonical SAM Cleavage and C-As Bond Formation. J. Am. Chem. Soc. 2024, 146, 21214-21219

18. Jiang, Y.; Yao, M.; Feng, J.; Niu, H.; Qiao, B.; Li, B.; Wang, B.*; Xiao, W.*; Dong, M.*, Yuan, Y. Molecular Insights into Converting Hydroxide Adenosyltransferase into Halogenase. J Agric Food Chem 2024, 72, 12685-12695

17. Yu, N.; Zhao H.; Wang, W.; Dong, M.*. Enzymatic fluoroethylation by a fluoroethyl selenium analogue of S-adenosylmethionine. ACS Catalysis. 2024, 14, 6211–6216

16. Jiang, Y.; Yao, M.; Niu, H.; Wang, W.; He, J.; Qiao, B.; Li, B.; Dong, M.*, Xiao, W.*; Yuan, Y. Enzyme Engineering Renders Chlorinase the Activity of Fluorinase. J Agric Food Chem 2024, 72, 1203-1212.

15. Wang, W.; Zhao H.; Yu, N.; Chen, F.; Dong, M.*. Stable S-Adenosylmethionine Analogue for Enzymatic Fluoromethylation. ACS Catalysis. 2023, 13, 13729-13734

14. Huang, R.; Zhi, N.; Yu, L.; Li, Y.; Wu, X.; He, J.; Zhu, H.; Qiao, J.; Liu, X.; Tian, C.; Wang, J *; Dong, M.* Genetically encoded photosensitizer protein reduces iron-sulfur clusters of radical SAM enzymes. ACS Catalysis, 2023, 13, 1240-1245.

13. Zhi, N.; Zhu, H.; Qiao, J.; Dong, M.* Recent progress in radical SAM enzymes: New reactions and mechanisms. Chin. Sci. Bull 2022, 67, 1806-1820

12. Li, Y.; Yao, Y.; Yu, L.; Tian, C.; Dong, M.* Mechanistic investigation of B12-independent glycerol dehydratase and its activating enzyme GD-AE. Chem. Commun., 2022, 58, 2738-2741

11. Zhou, S.; Chen, X.; Ni, X*.; Liu, Y.; Zhang, H.; Dong, M.*; Xia, H*. Pyridoxal-5´-phosphate-dependent enzyme GenB3 Catalyzes C-3´,4´-dideoxygenation in gentamicin biosynthesis. Microb. Cell. Fact. 2021, 20:65, 1-12.

10. Fenwick, M. K.; Su, Dan.; Dong, M.; Lin, H *; Ealick, S. E.* Structural Basis of the Substrate Selectivity of Viperin. Biochemistry 2020, 59, 652–662.

9. Dong M, Dando EE, Kotliar I, Su X, Dzikovski B, Freed JH, Lin H. The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis. J. Biol. Inorg. Chem. 2019, 24, 777-782.

8. Fenwick, M. K.; Dong, M.; Lin, H.; Ealick, S. E.*. The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis. Biochemistry 2019, 58, 4343–4351.

Select Publications Before 2019

7. Dong, M.; Kathiresan, V.; Fenwick, M. K.; Torelli, A. T.; Zhang, Y.; Caranto, J. D; Dzikovski, B.; Sharma, A.; Lancaster, K. M.; Freed, J. H.; Ealick, S. E.; Hoffman, B. M.; Lin, H. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science 2018. 359, 1247-1250.

6. Dong, M.; Zhang, Y.G.; Lin, H. Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis. Methods Enzymol. 2018, 606, 421-438.

5. Dong, M.; Zhang, Y.G.; Lin, H. Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis. Biochemistry 2018. 57, 3454–3459. (Invited Perspective).

4. Dong, M.; Horitani, M.; Dzikovski, B.; Freed, J. H.; Ealick, S. E.; Hoffman, B. M.; Lin, H. Substrate-Dependent Cleavage Site Selection by Unconventional Radical S Adenosylmethionine Enzymes in Diphthamide Biosynthesis. J. Am. Chem. Soc. 2017. 139, 5680-5683

3. Dong, M#.; Horitani, M#.; Dzikovski, B.; Pandelia, M. E.; Krebs, C.; Freed, J. H.; Hoffman, B.; Lin, H. Organometallic complex formed by an unconventional radical SAM enzyme. J. Am. Chem. Soc. 2016. 138, 9755-9758.

2. Lin, Z.; Dong, M.; Zhang, Y.; Lee, E.; Lin, H. Cytochrome B5 reductase is a Dph3 reductase required for the tRNA wobble uridine modification. Nat. Chem. Biol. 2016. 12,995–997

1. Dong, M.; Su, X.; Dzikovski, B. G.; Dando, E. E.; Zhu, X.; Du, J.; Freed, J. H.; Lin, H. Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. J. Am. Chem. Soc. 2014, 136, 17547

招生信息

研究生导师类型

学术型硕导,专业型硕导,学术型博导,专业型博导

学术型硕士招生学科

0817Z1制药工程,0817]4合成生物学

学术型硕士招生研究方向

00不区分研究方向

专业型硕士招生学科

086000生物与医药(专业学位)

专业型硕士招生研究方向

01制药工程,03合成生物学


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