合成生物学；DNA合成技术与设备研发；植物人工染色体合成；人工细胞工厂

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河北省生物制造产业联盟副理事长；

中国植物生理与植物分子生物学会理事

开发基因编辑技术，设计构建人工细胞工厂，实现了植保素等植物源化合物的异源高效合成；探讨了生长素调控植物叶片细胞形态发生及生长素调控植物发育的机制。

国家重点研发项目 植物人工染色体的设计与构建 项目负责人

1 Jun Ma, Qiang Li, Lei Zhang, Sen Cai, Yuanyuan Liu, Juncheng Lin,Rongfeng huang, Yongqiang Yu, Mingzhang Wen*, Tongda Xu*,High auxin stimulates callus through SDG8-mediated histone H3K36 methylationin in Arabidopsis, Journal of Integrative Plant Biology,2022

2 Yuyin Chang, Xiaoyu Shi, Fei He, Tao Wu, Ling Jiang, Nodirali Normakhamatov, Avez Sharipov, Tianfu Wang*, Mingzhang Wen*, and Haji Akber Aisa*,Valorization of Food Processing Waste to Produce Valuable Polyphenolics, J. Agric. Food Chem. 2022, 70, 29, 8855–8870

3 Ruiqi Chen , Jingru Wang, Junsong Xu, Shengxin Nie, Chen Chen, Yukun Li, Yanni Li, Jianwei He, Weiguo Li*, Mingzhang Wen*, Jianjun Qiao*，Heterologous Biosynthesis of Kauralexin A1 in Saccharomyces cerevisiae through Metabolic and Enzyme Engineering，J. Agric. Food Chem., MAR 26 2024, Volume 72,Issue 13

4 Niu T.; Yan X.; Wang J.; Song H.; Cui Y.; Cai X.; Chang K. A.; Qiao J. #; Wen M. #; He J. # Engineering of Pichia pastoris for the de novo synthesis of the sesquiterpene zealexin A1 from methanol. ACS Sustainable Chem. Eng. 2024, 12

5 Guanglin Zhu†, Xinzhi Zhou†, Mingzhang Wen#,Jianjun Qiao#, Guo Li #, and Yuan Yao#，CRISPR–Cas13: Pioneering RNA Editing for Nucleic Acid Therapeutics，BioDesign Research，6 Sep 2024，Vol 6