DNA功能材料

生命分析

疾病诊疗

食品安全与大健康

合成生物学

本科生课程：DNA合成；

研究生课程：纳米生物技术概论

担任Extracellular Vesicle、Advanced Sensor and Energy Materials期刊青年编委。

获国家自然科学基金委优青、面上和青年项目资助，承担国家重点研发计划子课题、天津市自然基金项目等。已发表SCI论文70余篇，第一作者或通讯作者论文50余篇，包括Nat. Protoc. 1篇，Proc. Natl. Acad. Sci. U.S.A. 1篇，J. Am. Chem. Soc. 3篇，Angew. Chem. 3篇，Chem. Rev. 1篇，Acc. Chem. Res. 1篇，Sci. Adv. 1篇，Nat. Commun. 1篇，Adv. Mater. 4篇，Anal. Chem. 2篇等，已授权中国发明专利6项。撰写教材《核酸功能材料》（副主编）。入选天津市“131”人才工程、天津大学北洋学者-青年骨干项目和“攀登计划”。获中国化工学会科学技术奖“基础研究成果奖”二等奖。

国家优秀青年科学基金项目

国家自然科学基金面上项目

国家自然科学基金青年项目

国家重点研发计划项目

天津市自然基金项目

论著：

《核酸功能材料》《合成基因组学》

论文：

1) Jianpu Tang+, Xuemei Jia+, Qian Li+, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang*, Chi Yao*, A DNA-based hydrogel for exosome separation and biomedical applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120.

2) Chi Yao+, Rui Zhang+, Jianpu Tang, Dayong Yang*, Rolling circle amplification (RCA)-based DNA hydrogel, Nature Protocols, 2021, 16, 5460.

3) Nachuan Song+, Yiwen Chu+, Shuai Li, Yuhang Dong, Xiaoting Fan, Jianpu Tang, Yanfei Guo, Guangshuai Teng, Chi Yao*, Dayong Yang*, Cascade dynamic assembly/disassembly of DNA nanoframework enabling the controlled delivery of CRISPR-Cas9 system, Science Advances, 2023, 9, eadi3602.

4) Chi Yao+*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome, Nature Communications, 2022, 13, 7739.

5) Yanfei Guo, Siqi Li, Zhaobin Tong, Jianpu Tang, Rui Zhang, Zhaoyue Lv, Nachuan Song, Dayong Yang*, Chi Yao*, Telomerase-Mediated Self-Assembly of DNA Network in Cancer Cells Enabling Mitochondrial Interference. Journal of the American Chemical Society, 2023, 145, 23859.

6) Chi Yao+, Chenxu Zhu+, Jianpu Tang, Junhan Ou, Rui Zhang, Dayong Yang*, T lymphocyte-captured DNA network for localized immunotherapy, Journal of the American Chemical Society, 2021, 143, 19330.

7) Chi Yao+, Han Tang+, Weijian Wu, Jianpu Tang, Weiwei Guo, Dan Luo, Dayong Yang*, Double rolling circle amplification generates physically crosslinked DNA network for stem cell fishing, Journal of the American Chemical Society, 2020, 142, 3422.

8) Sen Yang+, Junlin Wu+, Zhongyu Wang, Yu Cheng, Rui Zhang, Chi Yao*, Dayong Yang*, A smart DNA hydrogel enables synergistic immunotherapy and photodynamic therapy of melanoma. Angewandte Chemie International Edition, 2024, 136, e202319073.

9) Chi Yao+, Hedong Qi+, Xuemei Jia, Yuwei Xu, Zhaobin Tong, Zi Gu, Dayong Yang*, A DNA Nanocomplex containing cascade DNAzymes and promoter-like Zn-Mn-Ferrite for combined gene/chemo-dynamic therapy, Angewandte Chemie International Edition, 2022, 61, e202113619.

10) Jianpu Tang+, Chi Yao+, Zi Gu, Sunghwan Jung, Dan Luo, Dayong Yang*, Super-soft and super-elastic DNA robot with magnetically-driven navigational locomotion for cell delivery in confined space. Angewandte Chemie International Edition, 2020, 59, 2490.

11) Rui Zhang+, Pin Hu+, Yuwei Xu, Ziqing Wang, Dayong Yang*, Chi Yao*, Light-Mediated Spatiotemporally Dynamic Assembly of DNA Nanostructures in Living Cells Regulates Autophagy. CCS Chemistry, 2024, 6, 1557.

12) Nachuan Song+, Xiaoting Fan+, Xiaocui Guo+, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*, A DNA/upconversion nanoparticle complex enables controlled co-delivery of CRISPR-Cas9 and Photodynamic Agents for Synergistic Cancer Therapy. Advanced Materials, 2024, 36, 2309534.