通过晶体工程结合量子化学计算，高效筛选目标药物的新型多组分固体形态，以期改善其理化性能

承担分子科学与工程专业的本科生选修课《功能材料物理性能》，32学时；

承担化学工程专业的研究生选修课《医药结晶化学》，32学时。

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01.New Salts and Cocrystals of Pymetrozine with Improvements on Solubility and Humidity Stability: Experimental and Theoretical Study

Di Wu, Jiulong Li, Yuntian Xiao, Xu Ji, Chang Li, Bei Zhang, Baohong Hou, Lina Zhou, Chuang Xie,Junbo Gong, and Wei Chen*

Cryst. Growth Des. 2021, 21, 2371−2388

02.Evaluation on Cocrystal Screening Methods and Synthesis of Multicomponent Crystals: A Case Study

Di Wu, Bei Zhang, Qichao Yao, Baohong Hou, Lina Zhou, Chuang Xie, Junbo Gong, HongXun Hao,and Wei Chen*

Cryst. Growth Des., 2021,21, 4531−4546

03.Enhanced Solubility, Dissolution, and Permeability of Abacavir by Salt and Cocrystal Formation

Xu Ji, Di Wu, Chang Li, Jiulong Li, Qin Sun, Dewu Chang, Qiuxiang Yin, Lina Zhou, Chuang Xie, Junbo Gong, and Wei Chen*

Cryst. Growth Des., 2022, 22, 428-440

04.Multicomponent Crystals of Clozapine with Improved Solubility: A Combined Theoretical and Experimental Strategy on Coformer Screening and Structure−Property

Chunrong Li, Chuntao Zhang,* Yirui Yan, Wendong Liang, Jikun Xu, and Wei Chen*

Cryst. Growth Des. 2023, 23, 7295−7315

05.Multicomponent Crystal Screening and Performance Testing of Sunitinib: A Combined Virtual and Experimental Study

Huiwen Yang, Menglong Zhang, Liang Zhang, Fuhai Yu, Xinyu Hou, Ziqi Pan, Chuang Xie, Junbo Gong, Chuntao Zhang* and Wei Chen*

Cryst. Growth Des. 2024,24, 8112

做为国家重点研发计划《天然绿色生物农药合成生物学与组合合成技术》子课题《高效生物农药结晶工艺技术研究》(2017YFD0201406-02)项目负责人。

做为国家科技重大专项《药物一致性评价关键技术与标准研究》子课题《药物粒度、晶型的确定以及在仿制药一致性评价中的应用》(2017ZX09101001)项目负责人。

A.一种烟嘧磺隆-尿素共晶及其制备方法

陈巍，张蓓，侯宝红，吴迪，周丽娜，谢闯，龚俊波，鲍颖，张美景.

中国发明专利，授权号 CN111978293B

B.吡蚜酮-对羟基苯甲酸共晶及其制备方法

陈巍，吴迪，侯宝红，李九龙，张蓓，龚俊波，周丽娜，鲍颖，谢闯，张美景

中国发明专利，授权号 CN112538070B

C.一种2-羟基苄胺-丁二酸的盐及其制备方法

陈巍, 李九龙, 纪旭, 李唱, 侯宝红, 周丽娜, 谢闯, 龚俊波, 鲍颖, 张美景

中国发明专利，授权号CN112898168B