功能高分子材料与药用辅料

聚合物合成工艺学；功能高分子材料

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完成一项国家自然科学基金项目（81371667）和863 项目的子课题（2012AA022501），完成一项天津市自然科学基金项目，发表SCI检索论文60余篇，已获发明专利9项。

863项目子课题的研究：制备了3种阳离子聚合物，采用功能性方法构建了多种功能性核酸递送系统，完成体外细胞水平评价和毒性评价，初步的小动物体内小核酸递送及药效研究。研究结果表明，核酸递送系统的生物相容性、内涵体逃逸能力和转染效率均得到提高。

论文：(1) Shangliang Chen, Shuangyang Li, Zhanpeng Ye, Yufeng Zhang, Shangdong Gao, Hui Rong, Jianhua Zhang, Liandong Deng, Anjie Dong. Superhydrophobic and superhydrophilic polyurethane sponge for wound healing. Chemical Engineering Journal, 446 (2022) 136985；(2) Qiu YX, Dong YL, Zhao S, Zhang JH, Huang PS, Wang WW, Dong AJ, Deng LD. N-dodecylated chitosan/graphene oxide composite cryogel for hemostasis and antibacterial treatment. Journal of applied polymer science, 2021, 138(24): e50572；(3) Wei SB, Liu X, Zhou JH, Zhang JH, Dong AJ, Huang PS, Wang WW, Deng LD. Dual-crosslinked nanocomposite hydrogels based on quaternized chitosan and clindamycin-loaded hyperbranched nanoparticles for potential antibacterial applications. INT J BIOL MACROMOL, 2020, 155: 153-162；(4) Jiang YJ, Zhou JH, Zhao XJ, Zhang JH, Guo RW, Dong AJ, Deng LD. Ultra-pH-Sensitive Biopolymer Micelles Based on Nuclear Base Pairs for Specific Tumor-Targeted Drug Delivery. Macromol. Chem. Phys. 2019, 220(21), 1900309；(5) Deng LD, Feng ZJ, Deng HZ, Jiang YJ, Song Kun, Shi YL, Liu SQ, Zhang JH, Bai SP, Qin ZH, Dong AJ. Rational Design of Nanoparticles to Overcome Poor Tumor Penetration and Hypoxia-Induced Chemotherapy Resistance: Combination of Optimizing Size and Self-Inducing High Level of Reactive Oxygen Species. ACS Appl. Mater. Interfaces 2019, 11, 31743−31754；(6) Zhang Y, Guan J, Wu JM, Ding S, Yang J, Zhang JH, Dong AJ, Deng LD. N-alkylated chitosan/graphene oxide porous sponge for rapid and effffective hemostasis in emergency situations. Carbohydrate Polymers, 2019, 219: 405-413；(7) Peng D, Gao HJ, Huang PS, Shi XG, Zhou JH, Zhang JH, Dong AJ, Tang H, Wang WW and Deng LD. Host-guest supramolecular hydrogel based on nanoparticles: co-delivery of DOX and siBcl-2 for synergistic cancer therapy. J Biomat Sci-Polym E, 2019, 30(10): 877-893； (8) Feng HL, Sun Y, Zhang JH, Deng LD∗, Dong AJ. Influence of supramolecular layer-crosslinked structure on stability of dual pH-Responsive polymer nanoparticles for doxorubicin delivery. J Drug Deliv Sci Tec, 2018, 45: 81-92；(9) Feng HL, Wang CR, Zhou JH, Liu JJ, Zhang JH, Guo RW, Liu JF, Dong AJ, and Deng LD. pH-Responsive Nanoparticles for Controllable Curcumin Delivery: The Design of Polycation Core with Different Structures. Macromol Chem Phys, 2018, 219(14): 1800062；(10) Zhao XQ, Deng LD, Deng HZ, Dong AJ, Wang WW, and Zhang JH. In Situ Template Polymerization to Prepare LiposomeCoated PDMAEMA Nanogels with Controlled Size, High Stability, Low Cytotoxicity, and Responsive Drug Release for Intracellular DOX Release. Macromol Chem Phys, 2018, 219: 1800071

专利：（1）邓联东，董岸杰，癸二酸酐与十八烷二元酸酐共聚物及其制备方法和应用，ZL 200710056732.2；（2）邓联东，董岸杰，翟英雷，蔺晓娜，两亲性三嵌段共聚物及制备方法和应用，ZL200810053015.9；（3）邓联东，郭术涛，刘莎莎，董岸杰，含环醚侧基的可生物降解两亲性嵌段共聚物及其制备方法和应用，ZL 201010200249.9；（4）邓联东，董岸杰，岳鑫业，ABC型两亲性生物降解聚酯三嵌段共聚物及制备方法和应用，ZL 200910070599.5；（5）邓联东，董岸杰，李晶晶，二氧化钛/阳离子聚合物核壳结构的电泳粒子及其制备方法， ZL 201110268650.0；（6）邓联东，董岸杰，邓宏章，同一侧基上含有西弗碱和巯基的双重敏感两亲性共聚物及其制备方法与应用， 201410456306.8；（7）邓联东，董岸杰，曹艳，含二硫键与酰腙键的双重敏感两亲性三嵌段共聚物及其制备方法与应用，ZL 201410401511.4 ；（8）邓联东，黄平升，董岸杰，一种用于同步放化疗的温敏原位复合凝胶及其制备方法与应用， 201510658002.4；（8）邓联东，周俊辉，董岸杰，张建华，一种甲基丙烯酸-3,4-二硫代羟己酯的衍生物及其制备方法与应用，2019105290910