1. 基因组组设计合成

2. 合成生物学使能技术

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聚焦超大基因组设计合成的难题，近年来，发明了CasHRA兆级基因组组装新技术，设计合成了一条254 kb的信息存储染色体，存储两张图片和一个视频，阐释了DNA信息存储染色体在细胞内的表观遗传学、三维组学和转录翻译等方面的系列特征，相关成果发表在Nucliec Acids Research、National Science Review、Chemical Science、Science China Life Science等期刊。

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1.Chen, Y., P. Ge, T. Sun, J. Feng, G. Li, J. Zhang, J. Zhou* and J. Jiang* (2023). "Coexpression of Tail Fiber and Tail Protein Genes of the Cyanophage PP Using a Synthetic Genomics Approach Enhances the Salt Tolerance of Synechocystis PCC 6803." Microbiol Spectr 11(3): e0500922

2.Ting Zhang#, Bonan Xu#, Jia Feng, Pingbo Ge, Guorui Li, Jiabao Zhang, Jianting Zhou*, Jianlan Jiang*. Synthesis and assembly of full-length cyanophage A-4L genome. Synth Syst Biotechnol, 2023, 8(1):121-128.

3.Jianting Zhou#, Chao Zhang#, Ran Wei#, Mingzhe Han, Songduo Wang, Kaiguang Yang, Lihua Zhang, Weigang Chen, Mingzhang Wen, Wei Tao*, Ying-Jin Yuan*. Exogenous artificial DNA forms chromatin structure with active transcription in yeast. Sci China Life Sci, 2022, 65(5):851-860.

4.Shujing Liu#, Jia Feng#, Tao Sun, Bonan Xu, Jiabao Zhang, Guorui Li, Jianting Zhou*, Jianlan Jiang*. The Synthesis and Assembly of a Truncated Cyanophage Genome and Its Expression in a Heterogenous Host. Life (Basel), 2022, 12(8).

5.Ze-Xiong Xie#, Jianting Zhou#, Juan Fu#, Yin-Jin Yuan*. Debugging: putting the synthetic yeast chromosome to work. Chem Sci, 2021, 12(15):5381-5389.

6.Weigang Chen#, Mingzhe Han#, Jianting Zhou#, Qi Ge, Panpan Wang, Xinchen Zhang, Siyu Zhu, Lifu Song, Ying-Jin Yuan*. An artificial chromosome for data storage. Natl Sci Rev, 2021, 8(5):nwab028.

7.Jianting Zhou#, Ronghai Wu, Xiaoli Xue*, Zhongjun Qin*. CasHRA (Cas9-facilitated Homologous Recombination Assembly) method of constructing megabase-sized DNA. Nucleic Acids Res, 2016, 44(14):e124.