核酸功能材料；

DNA动态组装；

智能递药系统

本科生课程：食品安全与质量控制

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研究方向面向生命健康对生物材料的应用需求，致力于设计并构建新型DNA功能材料，用于生命系统DNA组织构效关系研究、细胞内原位动态组装、精准创制多模块药物递送系统等。相关工作已在J. Am. Chem. Soc.、Angew. Chem.、Sci. Adv.、Adv. Mater.、Adv. Funct. Mater.、Aggregate等高水平期刊发表学术论文近20篇。申请发明专利9项，5项获得授权。主持国家自然科学基金青年项目等。

国家自然科学基金青年项目；

中国博士后科学基金面上项目

1. Xiaocui Guo#, Mengyu Guo#, Rong Cai*, Mingdi Hu, Le Rao, Wen Su, He Liu, Fene Gao, Xiaoyu Zhang, Jing Liu*, Chunying Chen*. mRNA compartmentalization via muti-module DNA nanostructure assembly augments the immunogenicity and efficacy of cancer mRNA vaccine. Science Advances, 2024, 10(47): eadp3680.

2. Xiaocui Guo#, Feng Li#, Chunxia Liu, Yi Zhu, Nannan Xiao, Zi Gu, Dan Luo, Jianhui Jiang, Dayong Yang*. Construction of organelle-like architecture via dynamic DNA assembly in living cells, Angewandte Chemie International Edition, 2020, 59, 46, 20651-20658.

3. Xiaocui Guo#, Feng Li#, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*. Gene circuit compartment on nano-interface facilitating cascade gene expression. Journal of the American Chemical Society, 2019, 141, 48, 19171-19177.

4. Meihe Yuan#, Yuhang Dong#, Zhaoyue Lv#, Jinqiao Liu, Xiaocui Guo*, Chi Yao*, Dayong Yang*. Controlled sequential assembly of DNA nanoparticles inside cells enabling mitochondrial interference. Advanced Functional Materials, 2024, 34(17), 2312880.

5. Nachuan Song#, Xiaoting Fan#, Xiaocui Guo#, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*. A DNA/Upconversion nanoparticle complex enables controlled co-delivery of CRISPR-Cas9 and photodynamic agents for synergistic cancer therapy. Advanced Materials, 2024, 36(15), 2309534.

6. Yanfei Guo#, Jinqiao Liu#, Yan Huang, Xiaocui Guo*, Dayong Yang*. Construction of DNA aggregates in cell milieu for bio-interference. Aggregate, 2023, e389.

7. Yanfei Guo#, Peiran Li #, Xiaocui Guo*, Chi Yao*, Dayong Yang*. Synthetic nanoassemblies for regulating organelles: from molecular design to precision therapeutics. ACS Nano, 2024.

8. Xiaocui Guo, Yi Zhu, Lihui Bai, Dayong Yang*. The protection role of magnesium ions on coupled transcription and translation in lyophilized cell-free system. ACS Synthetic Biology, 2020, 9, 4, 856-863.

9. Xiaocui Guo, Lihui Bai, Feng Li, Wilhelm Huck, Dayong Yang*. Branched DNA architectures produced by PCR‐based assembly as gene compartments for cell-free gene expression reactions. ChemBioChem, 2019, 20, 2597-2603.

10. Xun You#, Jing Wang#, Xiaocui Guo*, Dayong Yang*. Advances in rolling circle amplification (RCA)-based DNA functional materials for cancer diagnosis and therapy. Advanced NanoBiomed Research, 2024, 4, 3, 2300108.

11. Xiaoyan Li#, Xiaocui Guo#, Mingdi Hu, Rong Cai*, Chunying Chen*. Optimal delivery strategies for nanoparticle-mediated mRNA delivery. Journal of Materials Chemistry B, 2023, 11, 2063-2077.

12. Zhu Yi#, Xiaocui Guo#, Jinqiao Liu, Feng Li, Dayong Yang*. Emerging advances of cell-free systems toward artificial cells. Small Methods, 2020, 4, 2000406.