长期从事消化系统疾病抗体药物和活菌药物的理性设计、工艺开发和作用机制研究。

生物工程导论，专业课程设计

中国医药教育协会代谢药学专业委员会青年委员，欧洲克罗恩病与结肠炎组织会员（ECCO），美国胃肠病学协会会员(AGA)，中国生物物理学会会员，美国胰腺学会会员（APA）

Y-ECCO Best Abstract Awards 2024获得者。在Biotechnology Advances、Gut Microbes、Advanced Optical Materials和International Journal of Biological Macromolecules等期刊发表SCI论文20余篇，参与国家及省部级项目7项，担任Cell Communication and Signaling等刊物审稿人。

国家重点研发计划子课题负责人，国家重点研发计划青年科学家项目校内负责人，天津大学启明计划项目负责人。

1. Guangbo Kang†, Xiaoli Wang†, Mengxue Gao†, Lina Wang, Zelin Feng, Shuxian Meng, Jiahao Wu, Zhixin Zhu, Xinran Gao, Xiaocang Cao*, He Huang*. Propionate-producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti-inflammatory macrophage via the GPR43/HDAC1/IL-10 axis[J]. Bioengineering & Translational Medicine,2024, e10682.

2. Jiewen Wang†, Guangbo Kang†, Huiying Lu†, Ario de Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, Yuli Wang, Miao Zhang, Ping Wang, Yuanhang Feng, Zhanju Liu*, Xiaocang Cao*, He Huang*.Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-α and IL-23p19 bioactivities[J]. Clinical and Translational Medicine, 2024, e1636.

3. Zhichao Gong†, Guangbo Kang†, Ruijie Shi, Xu Jiang, Xuejiao Rong, Xiaobing Du, Jiang Wu, He Huang*, and Shuxian Meng*. Intermolecular Interaction Between BODIPY and TPE Enhances Phototherapy[J]. Advanced Optical Materials, 2024, 2303033.

4. Jiahao Wu†, He Huang†, Lina Wang, Mengxue Gao, Shuxian Meng, Shaolan Zou, Yuanhang Feng, Zeling Feng, Zhixin Zhu, Xiaocang Cao*, Bingzhi Li*, and Guangbo Kang*. A tailored series of engineered yeasts for the cell-dependent treatment of inflammatory bowel disease by rational butyrate supplementation[J]. Gut Microbes, 2024, 16(1):2316575.

5. Xiuzhao Chen†, Mengxue Gao†, Lina Wang†, Guifen Qiang, Yili Wu, He Huang*, and Guangbo Kang*. A synthetic microbial consortium protects against obesity by regulating vitamin B6 metabolism[J]. Gut Microbes, 2024, 16(1):2304901.

6. Jiaqi Li†, Guangbo Kang†, Jiewen Wang, Haibin Yuan, Yili Wu, Shuxian Meng, Ping Wang, Miao Zhang, Yuli Wang, Yuanhang Feng, He Huang*, Ario de Marco*. Affinity maturation of antibody fragments: A review encompassing the development from random approaches to computational rational optimization[J]. International Journal of Biological Macromolecules, 2023, 247: 125733.

7. Zhuoce Dang†, Mengxue Gao†, Lina Wang, Jiahao Wu, Yufei Guo, Zhixin Zhu, He Huang*, Guangbo Kang*. Synthetic bacterial therapies for intestinal diseases based on quorum- sensing circuits[J]. Biotechnology Advances,2023,65:108142.

8. Zelin Feng†, Guangbo Kang†, Jiewen Wang, Xingjie Gao, Xiaoli Wang, Yulin Ye, Limin Liu, Jingwen Zhao, Xinjuan Liu, He Huang*, Xiaocang Cao*. Breaking through the therapeutic ceiling of inflammatory bowel disease: Dual-targeted therapies[J]. Biomedicine & Pharmacotherapy,2023,158:114174.

9. Zixuan Bai†, Jiewen Wang†, Jiaqi Li, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang*, Ario de Marco*, He Huang*. Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations[J]. Computational and Structural Biotechnology Journal,2023,21:601-613.

10. Xiaocang Cao†, Ang Dong†, Guangbo Kang, Xiaoli Wang, Liyun Duan, Huixing Hou, Tianming Zhao, Shuang Wu, Xinjuan Liu*, He Huang*, Rongling Wu*. Modeling spatial interaction networks of the gut microbiota[J]. Gut Microbes, 2022, 14(1): 2106103.